• Nu S-Au Găsit Rezultate

Intra-operative application of ultrasonography combined with limited radiography for the treatment of supracondylar humerus fractures in children: a randomized controlled trial


Academic year: 2022

Share "Intra-operative application of ultrasonography combined with limited radiography for the treatment of supracondylar humerus fractures in children: a randomized controlled trial"


Text complet



Original papers

Intra-operative application of ultrasonography combined with limited radiography for the treatment of supracondylar humerus fractures in children: a randomized controlled trial

Yuan Li, Zongyi Wu, Xianhong Yi, Chenghuang Mao, Guangkui Yan, Mingqiao Fang, Tianlong Pan, Ruibo Zhu, Jingdong Zhang

Department of Orthopaedics Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, People’s Republic of China

Received 05.06.2021 Accepted 15.09.2021 Med Ultrason

2022, Vol. 24, No 2, 180-187

Corresponding author: Jingdong Zhang

The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Lucheng District, Wenzhou 325000, Zhejiang Province, People’s Republic of China

E-mail: [email protected]


Supracondylar humerus fractures are the most com- mon fractures around the elbow in children, constituting 60–65% of all fractures, with a peak incidence between 4 and 7 years of age [1]. According to Gartland’s classifi- cation and Wilkins Modification of Gartland’s classifica- tion, types 2b, 3a and 3b are generally treated surgically [2,3]. With the popularization of closed reduction and

percutaneous pinning in treating supracondylar humerus fractures, problems such as radiation exposure appear, threatening the patients’ and medical staff’s health. The risk of cancer mortality was estimated at 5% per Sievert for adults and up to 9.1% for a 10-year-old child, with increased risk for younger children [4-7]. This finding suggests that children are more sensitive to radiation ex- posure. Furthermore, it is difficult for surgeons to grasp the position and direction of internal fixation accurately when treating young children; therefore, the number of radioscopies may increase.

Furthermore, the younger the child is, the closer the body (especially the radiation-sensitive glands) to the radioactive source; therefore, radiation exposure may be higher. Orthopedic surgeons are five times more likely to develop cancer in their lifetime compared to other health- care workers due to occupational radiation exposure [8].

Increasing the distance between surgeon and the radio- Abstract

Aims: To introduce a new method of intra-operative application of ultrasonography (US) combined with limited radiog- raphy to treat supracondylar humerus fractures in children and evaluate its effect on radiation protection. Material and meth- ods: Fifty patients were randomly divided into the radiography-only group (RO group, n = 22) and the US combined with the limited radiography group (UR group, n = 28). US was performed to evaluate fracture displacement and to guide reduction in the UR group. The primary outcome measures were the average number of radiography instances and the quantitative value of radiation emission. Secondary outcome measures were length of hospital stays, loss of range of motion, loss of carrying angle, loss of Baumann angle, fracture healing time, pin site infection, compartment syndrome, cubitus varus, cubitus valgus, and iat- rogenic ulnar nerve injury. Results: Average number of radiography instances and quantitative value of radiation emission in the UR group decreased compared with the RO group (p<0.05). There were no significant differences between the groups re- garding mean time to surgery, the average length of hospital stays, average surgery time, radiological union time, Flynn grade, or loss of Baumann angle. Pin site infection was seen in one patient in the RO group and two patients in the UR group. No other complications occurred. Conclusion: Intra-operative application of US combined with limited radiography decreases radia- tion exposure during treatment of supracondylar humerus fractures in children without compromising the therapeutic effect.

Keywords: supracondylar humerus fractures; ultrasonography; radiography; radiation exposure; children DOI: 10.11152/mu-3300


them in a timely fashion, the surgeon’s protection will be reduced. For these reasons, it is essential to identify radiation-free methods that can guide the reduction of the fractures and monitor the position of the fragments in real-time.

Ultrasonography (US) is a radiation-free method that is used to diagnose diseases of the musculoskeletal sys- tem. It is characterized by real-time imaging, multiplanar capabilities, cost-effectiveness, patient comfort, noninva- siveness, portable and absence of radiation exposure. US dynamically displays and evaluates the anatomical rela- tionships between nerve and muscle in the elbow joint [11] and is a reliable method to examine the elbow joint, including the humeral-ulnar joint and the humeral-radial joint [12,13]. Our previous work demonstrated that the application of intra-operative US allowed monitoring of the reduction of femoral shaft fractures and guiding the insertion of elastic stable intramedullary nails [14]. Based on the previous studies, we aimed to study the intra-oper- ative application of US combined with limited radiogra- phy to treat supracondylar humerus fractures in children.

Material and methods Study design

The trial was a randomized controlled trial in which children with type 3 supracondylar humerus fractures were enrolled and treated by closed reduction and per- cutaneous pinning with the assist of intra-operative ap- plication of US or not. The trial was a single-center study conducted by a team of physicians experienced in pediat- ric orthopedic surgery, US or statistical analysis. Recruit- ment, randomization, surgery, follow-up, data collec- tion and statistical analysis were completed by different physicians. Written informed consent was obtained from all children’s parents or guardians following the World Medical Association Declaration of Helsinki. The Ethics Committee of the hospital granted permission for the use of ultrasonography during the surgeries.

Patient recruitment and sample size calculated An independent staff member who did not partici- pate in other study processes was appointed to recruit

patients. Inclusion criteria were type 3 supracondylar humerus fractures in children according to Gartland’s classification. At the time of consultation, there had been no more than 24 hours after the injury. Patients with multiple injuries, neurovascular damage, open fractures, cerebral palsy, previous injury of the homolateral elbow or other medical contraindications to surgery were ex- cluded. Patients present at the outpatient or emergency of the hospital from January 2018 to December 2018 were potential candidates. Patients who do not meet the cri- teria or refuse to participate in the study were excluded.

Furthermore, patients who were suspended from partici- pating in the trial or follow-up less than 12 weeks were also excluded. Finally, a total number of 50 patients were included in the study. A diagram of recruitment is dis- played in figure 1.


Randomization was done after the patient was un- der general anesthesia in the operating theatre, with the treating surgeon opening the assigned envelope. Before trial recruitment, randomization was performed for the expected trial population using a computer-generated list. Assigned allocation, US+radiography (UR) or radi- ography only (RO) group, was sealed in individual coded envelopes. The envelopes could not be opened until the patient was under general anesthesia.


The recruiter did not take part in the randomization, surgery, data collection, or statistical analysis. Patients were blinded to the primary choice of treatment but not to the treatment itself. Randomization and allocation were performed by the treating surgeon after induction of general anesthesia. Data collection during the surgery was not blind. Data collection after the surgery was per- formed by an independent physician and was blind. Sta- tistical analysis was performed by an independent statis- tician who did not participate in other study procedures.

Fig 1. Diagram of recruitment, randomization, allocation and follow-up.



Surgeries were performed by the same surgeons expe- rienced in pediatric orthopedic surgeries and US in both groups. All surgeries were performed within 24 hours of emergency visits in both groups.

RO group

Surgeries in the RO group were performed as per rou- tine. Briefly, after the induction of general anesthesia, the patient was maintained in the supine position with the elbow placed on the plate of the image intensifier. After preoperative preparation, longitudinal traction was ap- plied first with the forearm supinated to dislodge the frac- ture and gain length. Lateral extrusion and rotation of the distal fragment were subsequently performed to reduce lateral displacement and rotational malalignment. Then the elbow joint was flexed to restore the displacement on the sagittal plane. Radiography was then performed to judge the position of the fragments. Restoration and radiography was repeated until the reduction was satis- factory. Percutaneous lateral pinning using two or three diverging Kirschner wires was performed subsequently.

When the position of the Kirschner wires was not sat- isfactory, or the distal fragment was displaced again, restoration, radiography and adjustment of pinning were required until the fracture reduction, and fixation was satisfactory. During the process, intra-operative radiog- raphy could be repeated many times.

UR group

Surgeries of the UR group are described below. To clarify the feasibility of the technology to the greatest extent possible, we used images from more than one pa- tient. For the use of intra-operative ultrasonography, an M-Turbo, Portable Color Doppler Ultrasound System (SonoSite Co., America) with linear transducer of 7.0 to 11.0 MHz was employed. The frequency and depth were adjusted to obtain clear images. A sterile endoscope cover (Yafu Biological Technology Co., Ltd. Guang- zhou, Guangdong Province, China) was used to coat the

transducer, and sterile gel (Lijun Essence Pharmaceutical Co., Ltd. Xian, Shanxi Province, China) was used as a coupling agent to ensure sterile conditions. Pre-operative radiographs were carefully reassessed before the surgery (fig 2). After preoperative preparation, the preliminary reduction was performed according to the preoperative radiographs and the elbow was flexed maximally subse- quently.

Nevertheless, displacement of the fracture usually re- mained. Then, intra-operative US was performed to eval- uate the displacement of the fracture and the images were used as the references for further reduction. The nature of cortical bone causes the reflection of ultrasound waves and produces hyperechoic reflections from the bone surface. The position of the discontinuous hyperechoic reflection indicates the fracture site. The depth of the hy- perechoic reflection on the images indicates the distance between the fragments and transducer. Coronal scanning with the transducer placed longitudinally on the lateral elbow was first performed. The distal fragment deeper than the proximal fragment on the image indicates the medial displacement of the fracture (fig 3). By contrast, the distal fragment shallower than the proximal frag- ment on the image indicates the lateral displacement of the fracture. Then, sagittal scanning with the transducer placed longitudinally on the posterior of the elbow was performed. Shortening displacements were frequently seen for extension-type supracondylar fractures, and the distal fragment was shallower than the proximal fragment on the image (fig 4). With the two fragments adjacent at the fracture site, the apex against the transducer indicated hyperextension of the fracture (fig 5). By contrast, the two fragments adjacent at the fracture site but with the apex toward the transducer indicated hyperflexion of the fracture. To evaluate malrotation of the distal fragment, the transducer was placed longitudinally on the posterior lateral and posterior medial of the elbow to scan the distal fragment.

Fig 2. Pre-operative radiographs of the injured elbow: a) and b) supracondylar humerus fractures in a 6-year-old boy suggesting medial and posterior displacement and malrotation of the distal fragment; c) and d) supracondylar humerus fractures in a 9-year-old girl suggesting lateral displacement and hyperextension of the distal fragment after initial reduction and plaster immobilization.


was performed to confirm the reduction was satisfac- tory and percutaneous lateral pinning using two or three

diverging Kirschner wires was performed subsequently.

Radiography was performed for a final check before the finish of the surgery (fig 8). The subsequent process was performed as usual.


Follow-up was conducted at 2 and 4 weeks and then every other month to record the clinical results, radio- graphic results and complications.

Outcome measures

The primary outcome measures were the average number of radiography instances and the quantitative value of radiation emission. Radiography instances of each surgery were recorded. The average number of radi- ography instances of the two groups was calculated. The quantitative value of radiation emission of each surgery was calculated by recording the value of radiation pro- duced by each radiography. Secondary outcome meas- ures were length of hospital stays; clinical results such as excellent, good, fair or poor; radiographic results such as loss of Baumann angle, fracture healing time; complica- tions during the follow-up. Age, gender, the injured side, time to surgery between the groups were also compared.

Hospital stays were calculated as the length from admis- sion to discharge. Clinical results were graded as excel- lent, good, fair or poor according to the loss of range of motion and loss of carrying angle using the criteria of Flynn et al [15]. Loss of Baumann angle was calculated through the anteroposterior (AP) view. Loss of Baumann angle and clinical results were assessed at 12 weeks to get a true AP radiograph when most of the elbow could be fully extended, rather than at 4 weeks, when the elbow was stiff, which could influence the assessment of loss of ROM and loss of carrying angle. Radiographic fracture healing time was defined as continuous osteotylus forma- Fig 5. Hyperextension of the fracture: a) The transducer was placed longitudinally on the posterior elbow. The apex of hy- perechoic reflection (bold black arrow) against the transducer indicated hyperextension of the fracture: b) The lateral view of the radiograph confirmed the hyperextension of the fracture (fracture site, black bold arrow; distal fragment, bold white ar- row; proximal fragment, thin white arrow).

Fig 4. Shortening displacement of the fracture: a) the trans- ducer was placed longitudinally on the posterior elbow. Hy- perechoic reflection indicated that the distal fragment (DF) and the proximal fragment (PF) overlapped partially. Continuous periosteum (P) on the posterior elbow was seen under ultra- sonography; b) The lateral view of the radiograph confirmed the shortening displacement of the DF (fracture site, black bold arrow; periosteum, thin black arrow; distal fragment, white bold arrow; proximal fragment, thin white arrow).

Fig 3. Medial displacement of the distal fragment: a) the trans- ducer was placed longitudinally on the lateral elbow. The place where hyperechoic reflection is interrupted indicates the frac- ture site. The distal fragment (DF) was deeper than the proxi- mal fragment (PF), suggesting the distal fragment was medially displaced compared with the proximal fragment; b) anteropos- terior view of the radiograph confirming the medial displace- ment of the DF (fracture site, black bold arrow; DF, white bold arrow; proximal fragment, thin white arrow).


tion at the fracture site and the fracture line become in- definite on the radiograph. A complication was defined as any adverse event for which additional treatment was re- quired. Complications included compartment syndrome, cubitus varus, cubitus valgus, and iatrogenic ulnar nerve injury.

Statistical analysis

Statistical analysis was performed using Pearson’s chi-square test and the Student’s t-test. The normality of the data was tested and obeyed normal distribution. All

p-values were three-tailed, and the significance level was set at 0.05. The analyses were performed using the SPSS software ver. 18.0 (SPSS Inc., Chicago, IL, USA).


In the RO group, the number of randomly assigned participants was 26, and in the UR group, the number was 34. Twenty-two patients received intended treatment and were analyzed for the primary outcome in the RO Fig 6. Malrotation of the distal fragment. The transducer was placed longitudinally on the posterior lateral a) and posterior medial b) of the elbow to evaluate the depth of the distal fragment. The increase of the depth on the lateral part with the decrease of the depth on the medial part indicated pronation of the distal fragment. c) Lateral view of the radiograph confirming pronation of the distal fragment (fracture site, black bold arrow; distal fragment, bold white arrow; proximal fragment, thin white arrow).

Fig 7. Ultrasound images of the fracture after reduction. Scanning from the lateral side a), medial side b), and posterior of the elbow c).

Reduction of fracture manifesting as continuous cortical bone and smooth contour (fracture site, black bold arrow; distal fragment, white bold arrow; proximal fragment, thin white arrow).

Fig 8. Radiographs of final checks before completion of surgery. Anteroposterior and lateral views of the elbow showed that the displacements were corrected, and the fixations were satisfactory.


group; in the UR group, 28 patients received intended treatment and were analyzed for the primary outcome.

Four patients were excluded before analysis in the RO group because one patient withdrew informed consent and for three patients, follow-up less was than 12 weeks.

In the UR group, six patients were excluded before anal- ysis; three withdrew informed consent and three follow- ups were less than 12 weeks.

All cases included for statistical analysis were fol- lowed up for at least 21 weeks. The mean duration of fol- low up, demographic data, mean time to surgery, average surgery time and average length of hospital stays in the two groups are detailed in Table I.

Reduction with the assistance of US decreased ra- diation exposure. The average number of radiography, quantitative value of radiation emission, evaluation fol- lowing Flynn criteria, loss of Baumann angle, fracture’s radiological union time and pin site infections in the two groups are listed in Table I.

No patient developed compartment syndrome, cubi- tus varus, cubitus valgus, or iatrogenic ulnar nerve injury among the 50 patients, and no patient underwent repeated surgery to treat the fracture.


The use of mobile radiography for intra-operative imaging is essential for treating supracondylar humerus fractures by closed reduction and percutaneous pinning.

However, obtaining intra-operative images in real time comes at the cost of radiation exposure to patients and surgeons. It is widely accepted that surgeons exposed to low-dose radiation for long periods and children who have higher tissue radiosensitivity face long-term health risks. Current strategies to reduce radiation exposure include the application of the inverted C-arm and mini-

C-arm, surgeon control of image acquisition, pulsed fluoroscopy and image collimation, use of protective lead apparel, thyroid shields and lead goggles for both patients and surgeons, greater surgical experience and proper C-arm calibration [16-18]. It is worth mention- ing that the use of intra-operative US was intended to reduce radiation exposure rather than a substitute for all intra-operative radiography. In addition to reducing ra- diation exposure, intra-operative US could also be used to evaluate the integrity of the posterior cartilage hinge.

An intact cartilage hinge is helpful during the reduction of the fracture, and matching between the cartilage hinge and the bone surface is an indirect indication of fracture reduction. Moreover, when the fracture line extends from medial superior to lateral inferior, medial pinning may be applied, and intra-operative US could be used to monitor the position of the ulnar nerve to avoid iatrogenic injury.

The application of US in surgery is used to determine the position of the fragments and the process together with reduction may be performed repeatedly during the surgery. Therefore, the repetitive process of restoration and radiography in the UR group was changed to a repet- itive process of restoration and ultrasound scanning. In- tra-operative application of US dramatically reduces the number of radioscopies in this process. Type 3 humeral supracondylar fractures are highly unstable. Even if the reduction is satisfactory initially, the fragment may be displaced again during the percutaneous pinning. There- fore, after initial fixation, US can be used to evaluate the fragment position instead of radiography. Once the distal fragment is found to be displaced, the Kirschner wires need to be withdrawn and restoration and US performed again. US can replace radiography in this process again to further reduce radiation exposure.

In the present study, the primary reduction was per- formed according to pre-operative radiographs and the Quantitative value of radiation emission (μGy*m) 19.46 ± 6.32 4.78 ± 1.48 0.000*

Flynn grade (excellent/good) Loss of Baumann angle (degree) Radiological union time (weeks) Pin site infection

18/43.50 ± 1.06 4.23 ± 0.43 1

23/53.36 ± 0.91 4.36 ± 0.56 2

1.000 0.611 0.372 1.000



elbow was subsequently placed in hyperflexion to stabi- lize the fracture. As a result, US performed on the anterior elbow was limited. However, scanning the posterior and lateral elbow was sufficient to evaluate the displacement on a single plane. Reduction of the fracture manifested as continuous cortical bone with a smooth contour. Accord- ing to the position of the distal fragment on the image (above or below the proximal fragment), we can deter- mine whether the distal fragment is close or away from the transducer. According to the transducer position (lat- eral or medial side), we can determine whether the distal fragment is lateral or medial displacement. Determina- tion of torsional malalignment in all kinds of fractures is difficult sometimes under intra-operative radiography.

Ehrenstein T et al proposed using a modified transducer attached with a goniometer to assess torsional deformity [19]. However, the modified transducer and goniometer are not always available in every hospital. The method present in the study can also effectively determine the sit- uation of rotation. This method may be easier and more intuitive when two transducers are used simultaneously.

The results of our study suggested that the transducer did not extend the length of hospital stays, surgery time or bone union time, with an apparent decrease in radia- tion exposure. The functional outcomes and occurrence of complications were similar between the groups. The absence of other complications may be related to the small number of cases rather than a sign that the level of our surgeons is exceptionally high or that the use of the technique will decrease complications.

All surgeries were performed within 24 hours after the emergency visit. This was done to prevent compart- ment syndrome and reduce anxiety on the part of the pa- tients and their guardians. Moreover, the swelling of the elbow increases the difficulty of reduction and influences the ultrasound scanning, the transducer requiring a deli- cate and smooth operation to optimize imaging.

Furthermore, it also requires clear cognition of ultra- sound images. Surgeons should be capable of identifying normal tissues and the interference caused by hematomas and bone fragments. Three-dimensional imagination and integration capabilities are also required to provide an optimal grasp of the overall situation of the fracture. As long as repeated training is performed, this technique is not difficult to perform.

There were several limitations in the study, includ- ing the small number of cases in each group. The study was a single-center trial; the results may be influenced by the level of surgeons in the hospital. The clinical results were graded as excellent, good, fair, or poor according to the criteria of Flynn et al [15]. Nevertheless, whether the patient returned to the same function as before the

fracture remains unknown. Surgeons were not blinded to the treatment process, which may influence the result of radiation exposure. However, studies will be continued further to demonstrate the feasibility and advantages of the technique.


The application of intra-operative US for treating supracondylar humerus fractures can decrease radiation exposure without reducing therapeutic efficacy.

Acknowledgment: This work was supported by the Wenzhou Science and Technology Plan Project (Grant Y20170392).

Conflict of interest: none.


1. Beaty JH, Kasser JR. Fractures about the elbow. Instr Course Lect 1995;44:199-215.

2. Gartland JJ. Management of supracondylar fractures of the humerus in children. Surg Gynecol Obstet 1959;109:145- 3. Shenoy PM, Islam A, Puri R. Current Management of Pae-154.

diatric Supracondylar Fractures of the Humerus. Cureus 2020;12:e8137.

4. Giachino AA, Cheng M. Irradiation of the surgeon during pinning of femoral fractures. J Bone Joint Surg Br 1980;62- B:227-229.

5. Martus JE, Hilmes MA, Grice JV, et al. Radiation Expo- sure During Operative Fixation of Pediatric Supracondylar Humerus Fractures: Is Lead Shielding Necessary? J Pediatr Orthop 2018;38:249-253.

6. The 2007 Recommendations of the International Commis- sion on Radiological Protection. ICRP publication 103.

Ann ICRP 2007;37:1-332.

7. National Research Council of the National Academies.

Health risks from exposure to low levels of ionizing ra- diation: BEIR VII Phase 2. The National Academies Press, Washington, DC. 2006. doi:10.17226/11340.

8. Mastrangelo G, Fedeli U, Fadda E, Giovanazzi A, Scoiz- zato L, Saia B. Increased cancer risk among surgeons in an orthopaedic hospital. Occup Med (Lond) 2005;55:498-500.

9. Mehlman CT, DiPasquale TG. Radiation exposure to the orthopaedic surgical team during fluoroscopy: “how far away is far enough?”. J Orthop Trauma 1997;11:392-398.

10. Hafez MA, Smith RM, Matthews SJ, Kalap G, Sherman KP. Radiation exposure to the hands of orthopaedic sur- geons: are we underestimating the risk? Arch Orthop Trau- ma Surg 2005;125:330-335.

11. Radunovic G, Vlad V, Micu MC, et al. Ultrasound assess- ment of the elbow. Med Ultrason 2012;14:141-146.

12. Barr LL, Babcock DS. Sonography of the normal elbow.

AJR Am J Roentgenol 1991;157:793-798.


Joint Surg Am 1974;56:263-272.

16. Schmucker A, Chen R, Vachhrajani S, Martinek M, Albert M. Radiation exposure in the treatment of pediatric supra-

based method for the assessment of torsional differences following closed intramedullary nailing of femoral frac- tures. Skeletal Radiol 1999;28:336-341.



The diplomatic activities regarding the protection of American religious, educational, philanthropic institutions, the safety of American interests and missionary activities and

poses, with the help of a particular form of power. Re- flecting upon the ideas of James Davison Hunter, Hava Lazarus-Zafeh, Laurence L. Silberstein, Joan Scott, Lionel Caplan,

In such cases as divided cities or conflict prevention and post-conflict peace building, the leaders of different reli- gious communities having broad concerns about people beyond

Clinical evaluation of injectable platelet‐rich fibrin with connective tissue graft for the treatment of deep gingival recession defects: A controlled randomized

The study results concluded that the ACEIs are effective in lowering systolic and diastolic blood pressure, they reduce global cardiovascular risk through

Its connection to Wash who wanted to use it to cut the weeds but, not having one of his own, needed to borrow one from Sutpen, is symbolic for the agricultural system of

The complexities of establishing a complete range of motion in the elbow joint following the treatment of supracondylar humerus fractures, as well as the impact of physical

Moshe de Leon.(65) Therefore, in lieu of assuming that Jewish philosophy would, invariably, inhibit Jewish mysticism from using extreme expres- sions, there are examples of the

Toate acestea sunt doar o parte dintre avantajele in care cred partizanii clonarii. Pentru a si le sustine, ei recurg la o serie de argumente. Unul dintre ele are in atentie

The drop in the value of saturation magnetization is due to the presence of LAA surfactant on the surface of magnetite nanoparticles and also the smaller size

By contrast to Yeats’ central position at the time, as acknowledged agent of cultural power, Joyce’s resistance was catalyzed by the energy of self-exiling –a third space

The evolution to globalization has been facilitated and amplified by a series of factors: capitals movements arising from the need of covering the external

Using a case study designed for forecasting the educational process in the Petroleum-Gas University, the paper presents the steps that must be followed to realise a Delphi

Evaluation of patients’ response to pulsed radiofrequency treatment applied to the suprascapular nerve in patients with chronic shoulder pain. Randomized Controlled Trial

Key Words: American Christians, Christian Right, Christian Zionism, US-Israel Relations, Conservative Christians Theology, State of Israel, Jews, Millennial beliefs,

The number of vacancies for the doctoral field of Medicine, Dental Medicine and Pharmacy for the academic year 2022/2023, financed from the state budget, are distributed to

e) The doctoral thesis is officially submitted to the Doctoral School Secretariat, in printed and electronic format, together with the summary of the thesis in

The longevity of amalgam versus compomer/composite restorations in posterior primary and permanent teeth: findings From the New England Children’s Amalgam Trial..

Fluid distension of the trochanteric bursa appears as a well-circumscribed round-shaped hypoechoic to ane- choic collection located superficially to the posterior

Colour Doppler ultrasonography evaluation of vascularization in the wrist and finger joints in rheumatoid arthritis patients and healthy subjects.. Jacob D, Cohen M,

Osteosynthesis of the external ankle and revision of the ligaments of the tibiofibularsyndesmosis were performed in 9 (14.6%) patients with two-malleolar fractures

A total of 32 patients with acute three- or four-part displace fractures of the proximal humerus were treated with open reduction and internal fixation using the proximal

A randomized controlled trial was conducted on 20 Egyptian patients with severe UC according to truelove and witt’s criteria divided into two groups each one composed of 10