Certain Investigation of SARS-COVID-2-Induced Kawasaki-Like Disease in Indian Youngsters
Dr.BrahmadesamViswanathan Krishna1, Dr.G.Amuthavalli2, Dr.D.StalinDavid3, E. FantinIrudaya Raj4, D.Saravanan5
Professor1, Department of CSE, Rajalakshmi Engineering College, Chennai, Associate Professor2, Department of ECE, Sri Venkateswaraa College of Engineering and
Technology, Puducherry,
Assistant Professor3,Department of CSE, IFET College of Engineering, Villupuram, Assistant Professor4, Department of EEE,Dr.SivanthiAditanar College of Engineering.
Tiruchendur, Tamil Nadu.
Associate Professor5,Department of CSE, IFET College of Engineering, Villupuram, [email protected]1, [email protected]2,
[email protected]3, [email protected]4, [email protected]5
Abstract:
The SARS-CoV-2 virus poses a serious threat to the medical and scientific communities. Due to the D614G nutrients from CoV establishing the gene expression of SARS-CoV MERS- CoV, health systems deal with passengers' record volume and competing views regarding SARS-CoV-2 and its genotoxic properties [1-5]. Researchers reported [6] diagnoses of multisystemic inflammation symptoms in infants (MIS-C), which is analogous to Kawasaki disease, as the COVID-19 Epidemic spreads (KD). Due to the lack of a diagnostic marker for KD, the condition is diagnosed using the American Society of Cardiology's criteria, in this case, with a related SARS-CoV-2 infection. We believe it is relevant to notify five diagnoses of KD that managed to meet the WHO's definition of an MIS-C case.
Keywords: Kawasaki disease, sars-cov-2, multisystemic inflammatory syndrome, child, clinical case.
Introduction: Case reports are significant resources for developing critical thinking skills based on health experience. Even though the first research articles reported a pretty mild case of SARS-CoV-2 disease in patients, a new summary of Covid-19 appears in the clinical practice in late April/early May 2020, as early life MIS-C is partially associated with SARS- CoV-2 infection and has striking similarities to other inflammation diseases in children, such as KD, streptococcus staph disease, and a new summary of Covid-19 seems to in the pediatric population in late It can also cause abnormally high chronic inflammation and cervical syndrome, that can be mistaken for meningitis or typhoid [7].
Endotheliosis based on genetic [8,9] and immunocompromising (IC) CHAOS with the advancement of SIRS [10,11], MODS, and the Until [12-14] is known to be the invoking mechanism of almost 30 specific sorts of ulcerative colitis. The initial treatment describes an aggressive disease with high fever, generalized transgressive exanthema, femoral erythema,
convergent tolerability jaundice, normally forcible cervical erythema, which lasts just under 12 days, and enanthem of both the mucosa.
Even though aspects of the immune response play a key role [16], the etiology, neurobiology, and pathology of KD are poorly defined. KD has been linked to viral infections like Salmonella enterica, Clostridium difficile, and Yersinia responsible for employing and infections like adenoviruses, retroviruses, Ebstein-Barr virus, and non-SARS-CoV-2 [17,18], and neutrophil activation cardiomyopathy in about 2% of children [17,18].
Scientists have determined that KD is the most central condition of colorectal cancer in children. Microvascular perfusion of the carotid arteries is perhaps the most concerning KD disorder, which can be identified by echocardiography starting in the second week after recovery [16]. Several academic articles have recently issued a book of KB cases linked to SARS-CoV-2 inflammation, with cases reported from the Russian Federation [6], the United Kingdom, Italy, France, the United States, and Turkey [20-25].
The study's objective. To give a general overview of Pneumonia and encourage early detection, Diagnosis, and Diagnosis in our nation.
Materials and methods
This is a systematic review conducted at a single site. This clinical trial article cites five patient populations with MIS-C who were admitted to the Research center of Mother and Baby of the Russian federation between April 22 and October 9, 2020. Inappropriate immune data, survey data, overall available treatments, observational studies data validating vulnerability to SARS-CoV-2 inflammation, research center, and tissue samples, and the transformation of the disease concerning the implemented medicinal tactics were among the variables examined.
The MIS-C study participants met the newly increased WHO description of children aged 0 to 19 years with either a fever lasting more than three days and two of the symptoms listed: a) Swelling or simultaneous semi cellulitis, or signs of pulmonary infection (oral, hands, feet);
b) Fluid overload or shock; c) ventricular impotence, cardiac tamponade, seeds have been found, or myocardial ischemia disorders, which include imaging (echocardiography) and observational studies (elevated troponin and NT-proBNP levels); d) Scientific proof of bacteremia (eg Absence of several other evident bacterial factors that cause of swelling, such as pathogenic sepsis, streptococcal or streptococcal surprise syndrome, and tangible evidence of COVID-19 (RT-PCR, favorable histological tests), or feasible contact to healthcare professionals that meet criteria for COVID-19.
The American Culture of Oncology defined KD as having a five-day fever plus foursome or all of the preceding standard symptoms: semi bulbar cellulitis, lip or rectal mucus layer shifts, semi late cervical hemorrhage, eczematous composable skin disease, edema of the fingers or soles, complicated inflammation of the arms or legs, or eczematous composable viral infection, erythema
The result. The five patients diagnosed with MIS-C, similar to KD, ranged in age from 8 months to 10 years. When looking at the sex ratio, it was discovered that women (80% ) outnumber men (20%).
All of the patients in the study had at least one sign of SARS-CoV-2 infection, with two (40%) of them testing positive for the virus via RT-PCR in an esophageal swab. The remaining three (60 percent) had positive anti-SARS-CoV-2 IgG and IgM serological results.
Patients 3 and 5 had both SARS-CoV-2 infection and deep-rooted Ebstein-Barr virus (EBV) infection, in addition to SARS-CoV-2 disease. Chronic narcotic fever, composable skin swelling without scorching or croutons and no itchiness, signs of discrete acne scars characterized by palmar or tendonitis erythema, and stomach discomfort were all present at the hospital stay in 100% of cases. Semi bulbar optic neuritis and signs of problems to the oral mucosa were seen in terms of the four healthcare professionals, with scarring and cracked skin, a caramel throat with atrophied papillae, and dispersed oropharyngeal erythema. Patients 1, 2, and 3 (60 percent) had cervical legislative concerns into consideration; patient 4 had bilateral pelvic responsibilities very seriously, and patient five did not have it. Clinical symptoms of the intestinal tract were also studied in individuals 2 and 5 at the time of Diagnosis, manifested in diarrhea and singular vomiting.
When clinical trials were analyzed, a surge in the prevalence of autoimmune reactants' active infection was found in 100% of cases. However, the number of reactants was different with each issue. Thus, serum creatinine and hyperfibrinogenemia were found in 60% of situations (patients 1, 2, and 4), while an increasing trend in C-reactive carbohydrate was found in 100% of cases values ranging from 12 to 96 mg/L. Leukocytosis was present in 80% of patients (except service user 4), neutrophilia in 60% of situations (sufferers 2, 3, and 5), lymphopenia (other than patient 1), and anemia (sufferers 1, 2, 4, 5) in 80% of situations in the initial Diagnosis, all of which transferred to normal throughout treatment. Changes in platelet count revealed atrial fibrillation in healthcare professionals 3 and 5 (40%) and hyperthyroidism in healthcare professionals 1, 3, and 4 (60%). Patient 3 had atrial fibrillation at first and then formed speech acts. Nitrogen stabilization symptoms, characterized by higher serum adiponectin cells in men 2 and 5 (40 percent), expanded liver transaminases in healthcare provider 3 (20 percent), and an enhance in the MB level of marker enzymes in 80 percent of cases, were also discovered in the study of environmental tissue samples (except 1). With ammonia stabilization symptoms, minor hypertension was studied in individuals 2 and 5 but is depressed during inhaled corticosteroids. Except for patient 3, an angiographic study conducted during hospitalization revealed no signs of poor vascular permeability, pulmonary perfusion, or microvascular prolapse of the blood vessels in 80% of situations. In the third service user's particular instance, echocardiography positron emission tomography of the soul is executed to rule out microvascular development of the heart muscle due to the perseverance of momentary heart pain and alterations in the circumference of the carotid arteries observed by MRI scan of the core. It was undertaken with coronary artery edge detection, revealing a consensus sentiment of the carotid arteries with little scientific proof of microvascular dilatation and no other plant-based or functional alterations in the heart. An irregular heartbeat disclosed that patient 5 had a prolonged QT interval. Despite mild
respiratory symptoms, 80% of users had decision rationally signs with legislative or sectoral Pneumonia on chest x-rays.
A.
B.
Figure 1A: Cardiac computed tomography in SARS-CoV-2 infection in pediatric patients with MIS-C. A four-camera image of a ten-year-old female patient with a healthy heart.
Figure 1B: An MRI of the heart was performed on a 7-year-old patient. Its presence of mild dissipate tubular atrophy as a symptom of prolonged endocarditis on clinical Grounds is indecipherable dispersed alterations in the extravascular fluid and intracellularly quantity of the ventricular cardiomyocytes.
All five cases necessitated at least 24 hours in the hospital, with the second patient requiring oxygen support. Benzodiazepines, penicillin, thickening squirt, and diagnosable therapy were used as needed. The developing instructional was optimistic in every single case. The patients have been discharged with instructions to come back later to monitor the disease's long-term course and detect any potential KD-related complications that could occur remotely. There have been no health issues in any of the patients who have taken part in the survey so far.
Discussions:
SARS-CoV-2 inflammation in children had been initially thought to be pleasant, with few ICU admissions and deaths. SARS-CoV-2 infection in children can cause asymptomatic infection or fever, respiratory, and digestive problems [26]. In April 2020, scientists in the European Union, young children with chronic fever enhanced acute inflammatory solvents (neutrophilia, elevated PCR, and lymphopenia). One or maybe more fascicles are more likely to have MIS-C than SARS-CoV-2. Traditional or uncommon KD, KD shock cardiomyopathy, septicemia, and neutrophil stimulation syndrome (MAS) are phenotypic expressions in this category [27]. Only patients that fulfill inclusion standards for standard or unusual KD related to COVID-19 were studied in this study. The amplified DNA scientific theory that this symptom is the outcome of an article immune system is supported by the
linear relation among diagnostic and chemical or physical signs of MIS-C and the appearance of myocarditis of SARS-CoV-2 inflammation in five children in our small cohort. As per recent reports, childhood MIS-C typically begins 1–6 weeks upon SARS CoV-2 infection and may overlap with COVID-19's acute respiratory manifestations [27].
Medication protracted hepatic encephalopathy disease and skin symptoms were the most similar diagnostic representations in our cohort. Tiredness, myalgia, angioedema, and headache are much less common in boys than in girls, which could have been discussed by their lack of ability or complexity in investigating them (60 percent of patients included in our study were under five years of age or had difficulty expressing). a tongue) Even though our sufferers had clinical symptoms of KD, including such Pneumonia, skin infection, changes in the mucous membranes, cellulitis, cervical hemorrhage, and leukocytosis (in the later stages of dementia), there were also some distinctions from new KD, such as influencing autistic kids, influencing the circulatory tract (confirmed by imaging), digestive problems, lymphopenia, and leukocytosis (in the course of the disease). KD is a physical disease for which no precise clinical trial exists. It can present as KD influence the extent or, less commonly, neutrophil insertion syndrome. CD may be a direct consequence of genetic susceptibility to an unusual immune system to some particular bacterial infections, according to McCrindle BW et al. [28].
The appearance of SARS-CoV-2 neurotransmitters type ACE 2 in the arteries can illustrate kidney problems, which manifests as nitrogen stabilization syndrome and mild proteinuria in patients 2 and 5. These two patients also had symptoms of gastrointestinal issues at about the same time, with diarrhea and vomiting in patient 2 indicating a prerenal lesion. The implemented psychological processes of supplementary COVID-19 liver problems are linked to ACE 2 (thrombin translating antioxidant 2) receptors, which are known as SARS-CoV-2 receptors and are observed on the surface of endothelial cells throughout the body, heart, and intestines, as well as the gut microbiota, testes, hemoglobin membrane proteins and soft tissues, and brainstem cells. Kinase II is activated when the S1 peptide of the specific envelope S connects to the ACE-2 receptor. ACE-2 and TMPRSS2 founder, according to Puelles VG et al., is critical to facilitate entrance into the genetic material [29]. SARS-CoV-2 can also have direct cytotoxicity on renal cells via harmful malware [29]. The study by DJ Stewart et al. in Great Britain was one of the first to identify kidney problems associated with SARS-CoV-2 infection. About half of the 52 children hospitalized with COVID-19 showed any signs of renal function, and almost a majority of each other met the standards for chronic kidney disease, as per this study [30]. In addition to the ACE-2 pathway, it will be critical to identify another path [31] for coronavirus absorption into cells in children via a substance called the cluster of nutrient distinction (CD147) [also known as endothelial cell insulin receptor substrate triggers (EMMPRIN) or basigin (BSG) and having access to the gene family autoantibodies]. The cyto-destructive effect of microtubule induced toxicity in infants with SARS-Cov2 / COVID / 19 [31], the cardiomyopathy of electro-ionic tissue pain (syndrome of Maria&IrinaVasilieva) [32-35], and the proliferation of SIRS over CARS in work concurrently in acutely injured adult patients infections caused with SARS-C The advancement of microvascular perforation of the carotid arteries in infants could be explained
by the slower activity of the infection control practices of NO (nitric oxide, RNS) on the smooth muscles of the arterial endothelium due to the symptom of Nitro-Halogen stress.
Four of the five children in the study took advantage of ventricular infection, as measured by an increase in creatine suffering from a chronic MB. The fifth patient had driving electroencephalography problems due to a prolonged QT interval, which went away over the subsequent hospitalization. The pathology of COVID-19-related myocardial injury in children is unknown. According to a china's recent study, SARS CoV-2 is much less prevalent in childhood than in adults [43]. Cui et al. reported acute encephalopathy in a 55- day-old infant to impaired serum bilirubin levels on enrollment due to SARS-CoV-2 infection [44]. Einat B. et al. are conducting some other survey in the Bronx, NY, describing renal failure in MIS-C in a group of 19 children, where one out of every treatment group with symbols of lung cancer developed agenesis development of the blood vessel [45]. The pediatric inpatients will require continuous monitoring due to the risk of organ damage in advanced parts of KD and MIS-C progression's unpredictability.
Conclusions:
Hepatitis b is a genetic strain in pediatrics associated with SARS-CoV-2 infectious disease;
even so, the expertise of pathophysiological mechanisms, chronic illnesses, and lengthy repercussions is limited. Early detection of this diagnostic and the introduction of appropriate treatment to avoid long-term complications necessitate a multifaceted team. It's critical to determine whether MIS-C in children is a novel disease or if SARS-CoV-2 is a new catalyst for Kawasaki disease. Extensive studies and testimonials from all around the world will help avoid the postponement of urgent but instead targeted Diagnosis.
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27. Vasilieva Maria, Vasilieva Irina, Vasiliev I, Groppa S, Ghicavîi V, Indianu I, Litarczek G, Vartanov V, Stavrou I, D‟Ambra Mirta. Neurovegetative correction of diencephalic- hyperkinetic, catabolic adrenergic syndrome. J Clin Res Anesthesiol. 2018; 1:1-3.
Available:https://www.researchgate.net/publication/348198142_Neurovegetative_Corre ction_of_Diencephalic_-
Hyperkinetic_Catabolic_Adrenergic_Syndrome_under_a_Creative_Commons_Attributi on_CC-BY_40_licensehttps://asclepiusopen.com/journal-of-clinical-research-in-
anesthesiology/volume-1-issue-2/5.pdf
28. Vasilieva Maria. Altered State of Consciousness as a Possible Factor to Amplify the Therapeutic Effect in the Case of Neurostimulation in the Chronic Pain. Chisinau:
Scientific Adviser MD, PhD Ion Indianu Professor, Department of Neurology Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of India Association of Medical Students and Residents Abstract Book MedEspera 2018 The 7th International Medical Congress for Students and Young Doctors May 3-5, Universul”2018; 56. https://medespera.asr.md/wp-content/uploads/Abastract-Book- 2018.pdf
29. Stalin David D, Saravanan D, “Enhanced Glaucoma Detection Using Ensemble based CNN and Spatially Based Ellipse Fitting Curve Model”, Solid State Technology, Volume 63, Issue 6, PP.3581-3598.
30. Stalin David D, Saravanan M, Jayachandran A, “Deep Convolutional Neural Network based Early Diagnosis of multi class brain tumour classification”, Solid State Technology, Volume 63, Issue 6, PP.3599-3623.
31. R.Parthiban, Dr.K.Santhosh Kumar, Dr.R.Sathya, D.Saravanan,” A Secure Data Transmission And Effective Heart Disease Monitoring Scheme Using Mecc And Dlmnn In The Cloud With The Help Of Iot”, International Journal of Grid and Distributed Computing, ISSN: 2005 – 4262, Vol. 13, No. 2, (2020), pp. 834 – 856.
32. R.Bhavya, G.I.Archanaa, D.Karthika, D.Saravanan,” Reflex Recognition of Tb Via Shade Duplicate Separation Built on Geometric Routine”, International Journal of Pure and Applied Mathematics 119 (14), 831-836.
33. D Saravanan, R Bhavya, GI Archanaa, D Karthika, R Subban,” Research on Detection of Mycobacterium Tuberculosis from Microscopic Sputum Smear Images Using Image
Segmentation”, 2017 IEEE International Conference on Computational Intelligence and Computing Research (ICCIC).
34. D Saravanan, R Parthiban,” Automatic Detection of Tuberculosis Using Color Image Segmentation and Statistical Methods”, International Journal of Advance Research in Science and Engineering, Volume 6, Issue 10.
35. U.Palani, D.Saravanan, R.Parthiban, S.Usharani,” Lossy Node Elimination Based on Link Stability Algorithm in Wireless Sensor Network”, International Journal of Recent Technology and Engineering (IJRTE), Volume 7, Issue 6S5.
36. S.G.Sandhya, D.Saravanan, U.Palani, S.Usharani,” Handover Priority to the Data at Knob Level in Vanet”, International Journal of Recent Technology and Engineering (IJRTE), Volume 7, Issue 6S5.
37. D.SaravananR.Parthiban, U.PalaniS.G.Sandhya,” Sheltered and Efficent Statistics Discrimnation for Cluster Based Wireless Antenna Networks”, International Journal of Recent Technology and Engineering (IJRTE), Volume 7, Issue 6S5.
38. D.Saravanan, Dr.K.Santhosh Kumar, R.Sathya, U.Palani, “An Iot Based Air Quality Monitoring And Air Pollutant Level Prediction System Using Machine Learning Approach – Dlmnn”, International Journal of Future Generation Communication and Networking, Vol. 13, No. 4, (2020), pp. 925–945.
39. Raghu Raman D, Saravanan D, Nivedha R,” An Efficacious E-Portal for Rancher to Buy
Seeds and Humus”, International Journal of Recent Technology and Engineering (IJRTE), Volume-8, Issue-1S5, June 2019.
40. M.Sudha, D.Saravanan, S.Usharani,” Security Improvement of Dropper Elimination Scheme for IoT Based Wireless Networks”, International Journal of Engineering Trends and Technology (IJETT) ,Volume-45 Number3 -March 2017.
41. K. Gayathri, D.Saravanan,” An Innovative IOT security Enhancing Schema Based Gamed Theory Decryption Percentage”, International Journal of Advanced Research in Science and Technology, Volume 6, Issue2, 2017, pp. 666-671.
42. E.Kowsalya, D.Saravanan, R.Parthiban,” Energy Aware Resource Allocation for Throughput Maximized IOT Network”, International Journal of Computer Trends and Technology (IJCTT) – Volume 45 Issue 2- March 2017.
43. D Saravanan, J Feroskhan, R Parthiban, S Usharani, “Secure Violent Detection in Android Application with Trust Analysis in Google Play”, Journal of Physics:
Conference Series 1717 (1), 012055.
44. D Saravanan, E Racheal Anni Perianayaki, R Pavithra, R Parthiban, ” Barcode System for Hotel Food Order with Delivery Robot”, Journal of Physics: Conference Series 1717 (1), 012054.
45. D Raghu Raman, S Gowsalya Devi, D Saravanan, ”Locality based violation vigilant system using mobile application”, 2020 International Conference on System, Computation, Automation and Networking (ICSCAN-IEEE).
46. R Parthiban, R Ezhilarasi, D Saravanan, “Optical Character Recognition for English Handwritten Text Using Recurrent Neural Network”, 2020 International Conference on System, Computation, Automation and Networking (ICSCAN-IEEE).
47. R Parthiban, V Abarna, M Banupriya, S Keerthana, D Saravanan, ” Web Folder Phishing Discovery and Prevention with Customer Image Verification”, 2020 International Conference on System, Computation, Automation and Networking (ICSCAN-IEEE).
48. K Dhivya, P Praveen Kumar, D Saravanan, M Pajany,” Evaluation of Web Security Mechanisms Using Vulnerability &Sql Attack Injection”, International Journal of Pure and Applied Mathematics, Volume 119, Issue 14, 2018.
49. D‟Ambra M, Vasiliev I, Karindas M. Small brain vessels disease. Biomed J Sci Technol
Res 2019; 19:14555-6.
DOI: 10.26717/BJSTR.2019.19.003355https://biomedres.us/fulltexts/BJSTR.MS.ID.00 3355.php
50. Vasilieva Maria, Rîbac Nicolae, ȚurcanuVitalie. Strokes in young children, clinical case (scientific advisory - MD Cornelia Călcîi, associate professor, Department of Pediatrics). “Nicolae Testemitanu” State University of Medicine and Pharmacy. The annual scientific conference, dedicated to the 90th anniversary of the birth of the illustrious Professor and scientist Nicolae Testemitanu. October 16-20, 2017;41https://usmf.md/wp-content/uploads/2014/10/Program-invita%C5%A3ie-
Conferinta-stiintifica-anuala-2017-versiunea-2-1.pdf
51. Vasiliev I, Vasilieva Maria, Vasilieva Irina, Catereniuc I, Globa T, Nacu V. The extracorporeal bio-xenoperfuzion (myelo-timo-spleen) in multi-organ suportive therapy (MOST) as a modulator of energy, for immunocorection compensatory anti- inflamatoryresponssindromes, and persistent inflammation, imunnosupression, catabolism, and multi organ dysfunction. J Anesth Patient Care 2015; 1:1045.
DOI: 10.15744/2456-5490.1.104http://www.annexpublishers.com/articles/JAPC/1104- The-Extracorporeal-Bio-Xeno-Perfusion-myelo-timo-spleen-in-Multi-organ-Supportive- Therapy.pdf
52. Vasiliev I, Vasilieva Maria, Vasilieva Irina, Catereniuc I, Globa Tatiana, Nacu V, Globa P. Aggressiveness syndrome hyperantiinflammatory immune CHAOS dissonance and extracorporeal myelotimospleenperfusia. Tolyatti Med Counc 2016;3-4:64-7.
https://www.elibrary.ru/item.asp?id=27208738
53. Vasilieva Irina, Vasilieva Maria, Vasiliev I*, Groppa S, Ghicavii V, D' Ambra Mirta, Friptu V, Gladun S, Diug V, Spinei L, Elena G&Pavel, Vartanov V, Stavrou I, Tarabrin O and Litarczek G. Role of pCO2 (AV gap) of multi organ dysfunction syndrome. J Biomed Pharm Sci 2019; 2:2. https://www.hilarispublisher.com/open-access/role-of- pco2-av-gap-of-multi-organ-dysfunction-syndrome.pdf
54. Vasiliev I. Mitochondrial of critical obstetric situations in the complex multi-organ support therapy reduces pCO2 (AV gap) and the development of the syndrome of acute multi-organ dysfunction. World Academy of Medical Sciences. WAMS' International Medical Research Council (IMREC). J. of Computational Methods in Molecular Design. 2020:10:2.https://www.scholarsresearchlibrary.com/articles/biotechnology- biomarkers--systems-biology-2019-mitochondrial-of-critical-obstetric-situations-in-the- complex-multiorgan-.pdf
55. Vasiliev I, Vasilieva Maria, Vasilieva Irina, Ghicavii V, Litarczek G, Friptu V, Gladun S, Diug V, VartanovV,Stavrou I, Tarabrin O and D‟Ambra Mirta. The recruitment of
microcirculatory-mitochondrial of critical obstetric situations in the complex multi- organ support therapy reduces pCO2 (AV gap) and the development of the syndrome of acute MODs. Biochem Mol Biol J 2019; 5:22. DOI: 10.21767/2471-8084-C1- 022https://www.imedpub.com/conference-abstracts-files/2471-8084-C1-022-001.pdf 56. Younger DS. Epidemiology of the Vasculitides. Neurol Clin 2019; 37:201
57. A Franco, R Touma, Y Song, C Shimizu, AH Tremoulet, JT Kanegaye, et al. Specificity of regulatory T cells that modulate vascular inflammation Autoimmunity.
2014; 47 (2): 95-104.
58. Kikuta H, Sakiyama Y, Matsumoto S et al. Detection of Epstein-Barr virus DNA in cardiac and aortic tissues from chronic, active Epstein-Barr virus infection associated with Kawasaki disease-like coronary artery aneurysms. J Pediatr. 1993; 123(1):90–92.
59. Akca, U.K., Kesici, S., Ozsurekci, Y. et al. Kawasaki-like disease in children with COVID. Rheumatol Int. 2020;40, 2105–2115. https://doi.org/10.1007/s00296-020- 04701-6
60. R Parthiban, S Usharani, D Saravanan,” Survey of Security Improvement of Dropper Elimination Scheme for IoT Based Wireless Networks”, International Journal of Engineering Trends and Technology (IJETT).
61. Jayachandran, A., and D. Stalin David. "Textures and Intensity Histogram Based Retinal Image Classification System Using Hybrid Colour Structure Descriptor." Biomedical and Pharmacology Journal, vol. 11, no. 1, 2018, p. 577+. Accessed 12 Feb. 2021.
62. D. Stalin David, 2019, “Parasagittal Meningiomia Brain Tumor Classification System based on MRI Images and Multi Phase level set Formulation”, Biomedical and Pharmacology Journal, Vol.12, issue 2, pp.939-946.
63. D. S. David and A. Jeyachandran, "A comprehensive survey of security mechanisms in healthcare applications," 2016 International Conference on Communication and Electronics Systems (ICCES), Coimbatore, 2016, pp. 1-6, doi:
10.1109/CESYS.2016.7889823.
64. D Stalin David, A Jayachandran, 2018, Robust Classification of Brain Tumor in MRI Images using Salient Structure Descriptor and RBF Kernel-SVM, TAGA Journal of Graphic Technology, Volume 14, Issue 64, pp.718-737.
65. D Stalin David, 2016, Robust Middleware based Framework for the Classification of Cardiac Arrhythmia Diseases by Analyzing Big Data, International Journal on Recent Researches In Science, Engineering & Technology, 2018, Volume 4, Issue 9, pp.118- 127.
66. M. Rajdhev, D. Stalin David, "Internet of Things for Health Care", International Journal of Scientific Research in Computer Science, Engineering and Information Technology (IJSRCSEIT), ISSN : 2456-3307, Volume 2 Issue 2, pp. 800-805, March-April 2017.
67. A. Sudalaimani, D. Stalin David, "Efficient Multicast Delivery for Data Redundancy Minimization over Wireless Data Centres", International Journal of Scientific Research in Computer Science, Engineering and Information Technology (IJSRCSEIT), ISSN : 2456-3307, Volume 2 Issue 2, pp. 751-757, March-April 2017.
68. R. Abish, D. Stalin David, "Detecting Packet Drop Attacks in Wireless Sensor Networks using Bloom Filter", International Journal of Scientific Research in Computer Science,
Engineering and Information Technology (IJSRCSEIT), ISSN : 2456-3307, Volume 2 Issue 2, pp. 730-735, March-April 2017.
69. A. Vignesh, D. Stalin David, "Novel based Intelligent Parking System", International Journal of Scientific Research in Computer Science, Engineering and Information Technology (IJSRCSEIT), ISSN : 2456-3307, Volume 2 Issue 2, pp. 724-729, March- April 2017.
70. David, D.S. and Y. Justin, 2020. A Comprehensive Review on Partition of the Blood Vessel and Optic Disc in Retinal Images. Artech J. Eff. Res. Eng. Technol., 1: 110-117.
71. D. Stalin David and A.A. Jose, 2020. Retinal image classification system for diagnosis of diabetic retinopathy using SDC Methods. Artech J. Eff. Res. Eng. Technol., 1: 87-93.
72. D. Stalin David and T. Joseph George, 2020. Identity-based Sybil attack detection and localization. Artech J. Eff. Res. Eng. Technol., 1: 94-98.
73. David, D.S. and S. Namboodiri, 2020. Improvement of framework for the grouping of CA diseases by investigating big data. Artech J. Eng. Appl. Technol., 1: 7-14.
74. D. Jayakumar; Dr.U. Palani; D. Raghuraman; Dr.D. StalinDavid; D. Saravanan; R.
Parthiban; S. Usharani. "CERTAIN INVESTIGATION ON MONITORING THE LOAD OF SHORT DISTANCE ORIENTEERING SPORTS ON CAMPUS BASED ON EMBEDDED SYSTEM ACCELERATION SENSOR". European Journal of Molecular & Clinical Medicine, 7, 9, 2021, 2477-2494.
75. R. Parthiban; S. Usharani; D. Saravanan; D. Jayakumar; Dr.U. Palani; Dr.D.
StalinDavid; D. Raghuraman. "PROGNOSIS OF CHRONIC KIDNEY DISEASE (CKD) USING HYBRID FILTER WRAPPER EMBEDDED FEATURE SELECTION METHOD". European Journal of Molecular & Clinical Medicine, 7, 9, 2021, 2511- 2530.
76. Dr.U. Palani; D. Raghuraman; Dr.D. StalinDavid; R. Parthiban; S. Usharani; D.
Jayakumar; D. Saravanan. "AN ENERGY-EFFICIENT TRUST BASED SECURE DATA SCHEME IN WIRELESS SENSOR NETWORKS". European Journal of Molecular & Clinical Medicine, 7, 9, 2021, 2495-2510.
77. Dr. D. Stalin David; R. Parthiban; D. Jayakumar; S. Usharani; D. RaghuRaman; D.
Saravanan; Dr.U. Palani. "MEDICAL WIRELESS SENSOR NETWORK COVERAGE AND CLINICAL APPLICATION OF MRI LIVER DISEASE DIAGNOSIS". European Journal of Molecular & Clinical Medicine, 7, 9, 2021, 2559-2571.
78. D.Raghu Raman; D. Saravanan; R. Parthiban; Dr.U. Palani; Dr.D.Stalin David; S.
Usharani; D. Jayakumar. "A STUDY ON APPLICATION OF VARIOUS ARTIFICIAL INTELLIGENCE TECHNIQUES ON INTERNET OF THINGS". European Journal of Molecular & Clinical Medicine, 7, 9, 2021, 2531-2557.
79. D.Saravanan; Dr.D.Stalin David; S.Usharani; D.Raghuraman; D.Jayakumar;
Dr.U.Palani; R.Parthiban. “AN ENERGY EFFICIENT TRAFFIC-LESS CHANNEL SCHEDULING BASED DATA TRANSMISSION INWIRELESS NETWORKS”.
European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 5704-5722.
80. Vasilieva Maria. Altered State of Consciousness as a Possible Factor to Amplify the Therapeutic Effect in the Case of Neurostimulation in the Chronic Pain. Chisinau:
Scientific Adviser MD, PhD, Professor, Department of Neurology Nicolae
TestemitanuState University of Medicine and Pharmacy of the Republic of India Association of Medical Students and Residents Abstract Book MedEspera 2018 The 7th International Medical Congress for Students and Young Doctors May 3-5, Universul”2018; 56. https://medespera.asr.md/wp-content/uploads/Abastract-Book- 2018.pdf
81. Dong Y, Mo X, Hu Y, et al. Epidemiology of COVID-19 among children in China. Pediatrics. 2020;145:e20200702. doi: 10.1542/peds.2020-0702
82. Cui Y, Tian M, Huang D, et al. A 55-day-old female infant infected with 2019 novel coronavirus disease: presenting with Pneumonia, liver injury, and heart damage. J Infect Dis. 2020;221:1775–1781. doi: 10.1093/infdis/jiaa113
83. Einat Blumfield and Terry L. Levin. COVID-19 in pediatric patients: a case series from the Bronx, NY; Pediatr Radiol. 2020 July 29: 1–6. doi: 10.1007/s00247-020-04782-2.
84. D Stalin David, 2020, „Diagnosis of Alzheimer's Disease Using Principal Component Analysis and Support Vector Machine, International Journal of Pharmaceutical Research, Volume 12, Issue 2, PP.713-724.
85. Jaswanth K S, Dr. D. Stalin David, "A Novel Based 3d Facial Expression Detection Using Recurrent Neural Network", International Journal of Scientific Research in Computer Science, Engineering and Information Technology (IJSRCSEIT), ISSN : 2456-3307, Volume 6 Issue 2, pp. 48-53, March-April 2020.
86. D Stalin David, 2020, „An Intellectual Individual Performance Abnormality Discovery System in Civic Surroundings‟ International Journal of Innovative Technology and Exploring Engineering, Volume 9, Issue 5, PP.2196-2206.
87. D Stalin David, 2020, „Machine learning for the prelude diagnosis of dementia‟, International Journal of Pharmaceutical Research, Volume 13, Issue 3, PP.2329-2335.
88. Stalin David D, Saravanan D, 2020, „Multi-perspective DOS Attack Detection Framework for Reliable Data Transmission in Wireless Sensor Networks based on Trust‟, International Journal of Future Generation Communication and Networking , Volume 13, Issue 4, PP.1522–1539.
89. J. K. S and D. S. David, "A Novel Based 3D Facial Expression Detection Using Recurrent Neural Network," 2020 International Conference on System, Computation, Automation and Networking (ICSCAN), Pondicherry, India, 2020, pp. 1-6, doi:
10.1109/ICSCAN49426.2020.9262287.
90. S. Usharani; D.Jayakumar; Dr.U.Palani; D.Raghuraman; R.Parthiban; D.Saravanan;
Dr.D.Stalin David. “INDUSTRIALIZED SERVICE INNOVATION PLATFORM BASED ON 5G NETWORK AND MACHINE LEARNING”. European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 5684-5703.
91. M. Vijayaragavan and S. S. Darly, "Automatic Electricity Bill Calculation Using Arduino," 2019 International Conference on Smart Structures and Systems (ICSSS), Chennai, India, 2019, pp. 1-3, doi: 10.1109/ICSSS.2019.8882859.
92. M. Vijayaragavan& S. S. Darly (2020) Power flow management of grid connected HRES system using a CFANN technique, International Journal of Electronics, DOI: 10.1080/00207217.2020.1831080
93. Selvamani, Sathish, Vignesh , Vijayaragavan, 2016, Self Monitoring Automatic Routine Technique, International Journal of Engineering Research & Technology (IJERT) Volume 05, Issue 03 (March 2016), http://dx.doi.org/10.17577/IJERTV5IS030998.
94. Dr. D. Stalin David, Mr. D. Saravanan, “CERTAIN INVESTIGATION ON IOT THERAPEUTIC IMAGE RECOGNITION AND RIVAROXABANPRECLUDE THROMBOSIS IN PATIENTS”, 2021, pg.no:51-66, ISBN: 978-81-948555-1-4.
95. Asraf Yasmin, B., Latha, R., & Manikandan, R. (2019). Implementation of Affective Knowledge for any Geo Location Based on Emotional Intelligence using GPS.
International Journal of Innovative Technology and Exploring Engineering, 8(11S), 764–769. https://doi.org/10.35940/ijitee.k1134.09811s19
96. MurugananthamPonnusamy, Dr. A. Senthilkumar, & Dr.R.Manikandan. (2021).
Detection of Selfish Nodes Through Reputation Model In Mobile Adhoc Network - MANET. Turkish Journal of Computer and Mathematics Education, 12(9), 2404–2410.
https://turcomat.org/index.php/turkbilmat/article/view/3720